Core 2. Epidemiology and Prevention of CV Disease: Physiology, Pharmacology and LifestyleSession Title: Diabetes Mellitus and CVD: Prevention and Management I |
Abstract 19071: Impact of Angiotensin Receptor Blocker on Development of Glucose Intolerance and New-onset Diabetes Mellitus in Asian Population
Ji Young Park1; Seung Woon Rha2; Jae Woong Choi1; Sung Kee Ryu1; Byoung Geol Choi2; Se Yeon Choi2; Sung Il Im2; Sun Won Kim2; Jin Oh Na2; Seong Woo Han2; Cheol Ung Choi2; Hong Euy Lim2; Jin Won Kim2; Eung Ju Kim2; Chang Gyu Park2; Hong Seog Seo2; Dong Joo Oh2
1 Cardiology department, Eulji Univ, Eulji General Hosp, Seoul, Korea, Republic of
2 Cardiovascular Cntr, Korea Univ Guro Hosp, Seoul, Korea, Republic of
Background; Angiotensin receptor blocker (ARB) is being extensively used to control hypertension. But, there have been limited data whether ARB is associated with increased incidence of new-onset diabetes mellitus (DM) or impaired glucose intolerance (IGT).
Methods; We investigated total 13,561 patients (pts) that was glycerate hemoglobin level < 6.0% and fasting glucose level < 124 mg/dL (ARB therapy group=3421 and control group=9808) from January 2004 to February 2012. To adjust potential confounders, a propensity score matched analysis was performed using the logistic regression model. The primary end-point was the cumulative incidence of new-onset DM, IGT, and impaired fasting glucose (IFG). Also, multivariable cox-regression analysis by adjusted by aforementioned variables was performed to determine the impact of statin therapy on the incidence of new-onset DM, IGT, and IFG.
Results; Mean follow-up duration was 534±604 days in all-pt group, and 608±607 days in propensity score matching group. After propensity score match, total 5632 pts (ARB group=2816 and control group = 2816) were enrolled for analysis. Baseline characteristics was similar between the two groups except the more use of diuretics (38% vs. 35.5%, p=0.047). In Kaplan-Meyer curve, there was no difference between the two groups (p=0.428, figure A). Also, in cox-regression analysis performed in all pts, ARB therapy was not associated with the increased incidence of primary end-point (figure B).
Conclusions; In the present study, there was no clear association between ARB therapy and IGT or new-onset DM in a series of cardiovascular pts in Asian population.
Author Disclosures: J. Park: None. S. Rha: None. J. Choi: None. S. Ryu: None.B. Choi: None. S. Choi: None. S. Im: None. S. Kim: None. J. Na: None. S. Han:None. C. Choi: None. H. Lim: None. J. Kim: None. E. Kim: None. C. Park:None. H. Seo: None. D. Oh: None.
Key Words: Angiotensin II • Drugs
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